Research Assistant/Associate Scientist
Sionna Therapeutics is a clinical-stage biopharmaceutical company on a mission to revolutionize the current treatment paradigm for CF by developing novel medicines that normalize the function of the CFTR protein. Sionna’s goal is to deliver differentiated medicines for people living with CF that can restore their CFTR function to as close to normal as possible by directly stabilizing CFTR’s nucleotide-binding domain 1 (NBD1), which the company believes is central to potentially unlocking meaningful improvements in clinical outcomes and quality of life for people with CF. Leveraging over a decade of the co-founders’ extensive research on NBD1, the company is advancing a pipeline of novel small molecules engineered to correct the defects caused by the F508del genetic mutation, which resides in NBD1. Sionna is also developing a portfolio of complementary CFTR modulators that are designed to work synergistically with its NBD1 stabilizers to improve CFTR function.
Position Summary
Sionna Therapeutics seeks a creative and team-oriented Research Assistant/Associate Scientist who is results-driven, excels at critical thinking and problem solving, and has broad scientific experience, including demonstrable expertise in biochemical and molecular biology techniques and cell culture. The successful candidate will employ their diverse skillset to conduct studies, analyze data, and communicate results as part of a highly collaborative and multidisciplinary team engaged in cutting edge science. Responsibilities will also include aiding in the development of new scientific/technical approaches to meet key objectives. Strong communication skills are critical. Direct experience with protein production and/or primary cell culture is preferred.
We are accepting resumes for the position at careers@sionnatx.com.
Basic Qualifications:
Candidates should have a Bachelors in Biology or other relevant field, with a minimum of 4 years experience, or an M.S. in a relevant subject area with a minimum of 2 years additional experience. The successful candidate will have broad technical expertise, including advanced skill with and knowledge of a wide range of molecular, biochemical and cell biology methods. The successful candidate is expected to be able to work effectively in an energetic and friendly team environment. An eagerness to learn, attention to details and timelines, good verbal and writing skills are required.
Preferred Qualifications:
- Bachelors in Biology, or other relevant field, with a minimum of 4 years research experience, or an M.S. with a minimum of 2 years of additional research experience.
- A track record of problem solving, good organization and communication skills and an ability to collaborate effectively within multidisciplinary teams.
- A diverse technical and scientific background, preferably including solid technical skills across a range of desired cell, molecular and in vivo biology techniques:
- Protein expression – bacterial growth, induction, and isolation. FPLC techniques.
- Tissue Culture – growing and maintaining mammalian cells, direct experience with primary cell culture is a plus.
- Protein isolation and characterization by western blot
- Molecular biology techniques – cloning, DNA and RNA isolation, qPCR.
- Direct experience with pulse-chase labeling studies is desirable.
- Enthusiasm, desire to learn and contribute, strong commitment to and capacity for quality work.
